𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Applications of paired ion high-pressure liquid. Chromatography to catecholamines and phenylephrineapplications of paired ion high-pressure liquid

✍ Scribed by A. G. Ghanekar; V. Das Gupta

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
403 KB
Volume
67
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

Paired ion high-pressure liquid chromatography was useful for separating intact catecholamines (epinephrine, isoproterenol, levodopa, and methyldopa) and phenylephrine from some of their decomposition products. Furthermore, methyldopa was separated from either hydrochlorothiazide of levodopa. Under identical conditions without 1-heptanesulfonic acid (a counterion for paired ion chromatography) in the mobile phase, these separations were not possible. Paired ion chromatography also was tried successfully for the quantitative determinations of isoproterenol, levodopa, methyldopa, and phenylephrine in some dosage forms. The results were compared with the results obtained using some literature methods.

πŸ“œ SIMILAR VOLUMES

Ion pairing high-performance liquid chro
Ion pairing high-performance liquid chromatography of catecholamines
✍ Heady, Judith E. ;Agee, Karl D. πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 259 KB

## Abstract Catecholamine standards have been separated by ion pairing reversed‐phase high‐performance liquid chromatography (HPLC). A trace substance was separable from four standards when low concentrations of methanol were used in the elution buffer. This method has allowed separation of an unkn