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Applications of organolithium and related reagents in synthesis. Part 3. A general study of the reaction of lithium alkyls with pyridine ketones

✍ Scribed by Epsztajn, Jan; Bieniek, Adam


Book ID
121493710
Publisher
Royal Society of Chemistry
Year
1985
Weight
793 KB
Category
Article
ISSN
1472-7781

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Application of organolithium and related
✍ Adam Bieniek; Jan Epsztajn; Justyna A Kowalska; Zbigniew Malinowski πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 80 KB

The transformation of the benzanilides 1 into 4-arylisochroman-3-acetic acids 8 applying the following sequence of reactions is described. At first, the 3-arylphthalides 3 were obtained via metallation [n-BuLi] of benzanilides 1 and subsequent treatment of the generated bis-lithiated anilides 2 with