Application of organolithium and related reagents in synthesis. Part 7. Synthesis and metallion of 4-methoxypicolin- and 2-methoxyisonicotin-anilides. A useful method for preparation of 2, 3, 4-trisubstituted pyridines
✍ Scribed by Jan Epsztajn; Adam Bieniek; Mieczysław W. Płotka; Krzysztof Suwald
- Book ID
- 104204664
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 515 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
The transformation of the benzanilides 1 into 4-arylisochroman-3-acetic acids 8 applying the following sequence of reactions is described. At first, the 3-arylphthalides 3 were obtained via metallation [n-BuLi] of benzanilides 1 and subsequent treatment of the generated bis-lithiated anilides 2 with
AbstractÐThe synthesis of the 2-aryl-3-hydroxyisoindol-1-ones 3 and their successive conversion via the reaction with 1-methoxy-1trimethylsilyloxyethene in the presence of titanium(IV) chloride into 3-carboxymethylphthalimides 7 and subsequent cyclization via sequential treatment with oxalyl chlorid