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Applications of mass spectrometry to the characterization of oligonucleotides and nucleic acids

✍ Scribed by Pamela F Crain; James A McCloskey

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
977 KB
Volume
9
Category
Article
ISSN
0958-1669

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✦ Synopsis

Mass spectrometry-based techniques continue to undergo active development for applications to nucleic acids, fueled by methods based on electrospray and matrix-assisted laser desorption ionization. In the past two years, notable advances have occurred in multiple interrelated areas, including sequencing techniques for oligonucleotides, approaches to mixture analysis, microscale sample handling and targeted DNA assays, and improvements in instrumentation for greater sensitivity and mass resolution.

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