Applications of intramolecular amidomercuration. 3. Stereoselectivity in intramolecular amidomercuration. Kinetic vs. thermodynamic control
โ Scribed by Harding, Kenn E.; Marman, Thomas H.
- Book ID
- 121761701
- Publisher
- American Chemical Society
- Year
- 1984
- Tongue
- English
- Weight
- 381 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
Intramolecular conjugate addition of amide enolates to ct,l~-unsaturated esters was found to give either of the diastereomeric trans-3,4-disubstituted pyrrolidin-2-ones 6, 10 or 7, 11 as the major products, by choosing the appropriate reaction conditions. The cyclisation performed with Nail in THF a
The formation of tetrahydrofurans and tetrahydropyrans by acid catalyzed cyclization of hydroxy selenides can be explained by kinetic and thermodynamic control. The tetrahydropyrans from the hybrid 7-endo/6-exo cyclization are the thermodynamic products of the acid catalyzed cyclization of hydroxy s