Kinetic vs. thermodynamic control in intramolecular diene cyclozirconation: Synthesis of elemol.
β Scribed by Douglass F. Taber; Yanong Wang
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 359 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The formation of tetrahydrofurans and tetrahydropyrans by acid catalyzed cyclization of hydroxy selenides can be explained by kinetic and thermodynamic control. The tetrahydropyrans from the hybrid 7-endo/6-exo cyclization are the thermodynamic products of the acid catalyzed cyclization of hydroxy s
Diels-Alder cycloaddition of cyclopentadiene (1) to 2,3-dicyano-p-benzoquinone (2), when performed in methanol solvent at ambient temperature (kinetic control), gave 3b. Reduction of 3b, carried out under mild conditions by using CeCI3-NaBH4, proceeded stereospecifically to afford diol $. Subsequent
Intramolecular conjugate addition of amide enolates to ct,l~-unsaturated esters was found to give either of the diastereomeric trans-3,4-disubstituted pyrrolidin-2-ones 6, 10 or 7, 11 as the major products, by choosing the appropriate reaction conditions. The cyclisation performed with Nail in THF a