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Applications of capillary electrophoresis on microchip

✍ Scribed by Vladislav Dolnik; Shaorong Liu


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
971 KB
Volume
28
Category
Article
ISSN
1615-9306

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✦ Synopsis


Abstract

CE on microchip is an emerging separation technique that has attracted wide attention and gained considerable popularity. Because of miniaturization of the separation format, CE on chip typically offers shorter analysis time and lower reagent consumption with potential development of portable analytical instrumentation. This review with 143 references is focused on proteins and peptides analysis, DNA separation including fragment sizing, genotyping, mutation detection and sequencing, and also the analysis of low‐molecular‐weight compounds, namely explosive residues and warfare agents, pharmaceuticals and drugs of abuse, and various small molecules in body fluids.


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## Abstract This review article with 116 references describes recent developments in the preparation of wall coatings for capillary electrophoresis (CE) on a microchip. It deals with both dynamic and permanent coatings and concentrates on the most frequently used microchip materials including glass