Photodiode array liquid chromatography detectors are claimed to have the ability of evaluating the homogeneity of chromatographic peaks and this could provide a very powerful tool in support of method development. However, in pharmaceutical analysis, for this to be of practical value it must be capa
Applications of a miniaturized fluorimetric photodiode array detector for capillary liquid chromatography
β Scribed by Gluckman, J. C. ;Novotny, M.
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 520 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0935-6304
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β¦ Synopsis
A high sensitivity, multichannel fluorescertce detector with small volume has been developed for capillary column liquid chromatography. Using an intensified linear photodiode array to monitor fluorescence emission, several important mixtures exhibiting native fluorescence have been examined following high efficiency separation on a capillary colurnin. By correlating mass spectral, fluorescence spectral, and retention time data, information of potential utility in the structural elucidation of aromatic molecules contained in complex mixtures can be obtained. Examples include the separation and spectral examination of the polyaromatic compounds in samples of both biological and environmental interest.
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