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Applications of 1,4-addition of grignard reagents to α,β-unsaturated acid derivatives. III—configuration studies of α,β-diaryl-α,β-dialkylpropionitriles

✍ Scribed by Stanley Wawzonek; Edwin M. Smolin; Judith E. Durham

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
362 KB
Volume
6
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The configuration of twenty‐four different α,β‐diaryl‐α,β‐dialkylpropionitriles has been determined using nuclear magnetic resonance spectra. The erythro form showed greater deshielding of the methine hydrogen and alkyl groups in its spectra than the corresponding threo isomer. The former, however, showed less deshielding of the aryl groups than the threo isomer. Infrared spectra were not suitable for assignments of configuration.

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Enantioselective Copper-Catalyzed 1,4-Ad
Enantioselective Copper-Catalyzed 1,4-Addition of Grignard Reagents to α,β-Unsaturated Carbonyl Compounds
✍ Maurus Spescha; Grety Rihs 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 German ⚖ 693 KB

The enantioselective copper-catalyzed 1,4-addition of Grignard reagents to a$-unsaturated carbonyl compounds was studied with the following Cu' compounds as catalyst precursor and 1,2 : 5,6-di-0 -isopropylidene-3thio-a -o-glucofuranose (Hsiig) as chiral ligand: CuI, iodo[bis(dibutylsulfide)]copper(I