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Application of the two-dimensional nmr techniques on a des(Ala,Gly)-somatostatin analog

✍ Scribed by Yuji Kobayashi; Yoshimasa Kyogoku; Junji Emura; Shumpei Sakakibara

Publisher
Wiley (John Wiley & Sons)
Year
1981
Tongue
English
Weight
457 KB
Volume
20
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Two‐dimensional nmr techniques have been carried out for the peak assignment of the spectrum of a somatostatin analog. Two‐dimensional J‐resolved spectroscopy simplified the rather broad and complicated spectrum to show the center of chemical shifts of each resonance and gave information on the coupling profiles. Another technique, two‐dimensional spin‐echo correlated spectroscopy, revealed the connectivities between protons which are correlated by weak spin–spin couplings. The combination of the results of these two complementary techniques made it possible for us to assign almost all peaks of the spectrum of the 11‐residue somatostatin analog.

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