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Application of the Rh(II) Cyclization/Cycloaddition Cascade for the Total Synthesis of (±)-Aspidophytine

✍ Scribed by Mejía-Oneto, José M.; Padwa, Albert

Book ID
115314213
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
110 KB
Volume
8
Category
Article
ISSN
1523-7060

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Total Synthesis of the Alkaloid (±)-Aspi
Total Synthesis of the Alkaloid (±)-Aspidophytine Based on Carbonyl Ylide Cycloaddition Chemistry
✍ José M. Mejía-Oneto; Albert Padwa 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 German ⚖ 338 KB 👁 1 views

## Abstract The Rh^II^‐catalyzed cycloaddition cascade of an indolyl‐substituted __α__‐diazo imide was used for the total synthesis of the complex pentacyclic alkaloid (±)‐aspidophytine. Treatment of the resulting dipolar cycloadduct with BF~3~⋅OEt~2~ induces a domino fragmentation cascade. The rea