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Application of the grubbs ring-closing metathesis for the construction of a macrocyclic ansa-bridge. Synthesis of the tricyclic core of roseophilin

โœ Scribed by Seong Heon Kim; Israel Figueroa (in part); P.L. Fuchs

Book ID
104256791
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
235 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Metalation/alkylation of the pyrrole4used 10~ anion 15 regiospecifically yields the ~-alkylated ketones 16,17. Conversion of 17 to diene 24 followed by Grubbs ring-closing metathesis provides 29 which is transformed to the roseophilin tricyclic core structure 5.

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