Application of Ring-Closing Metathesis for the Synthesis of Macrocyclic Peptidomimetics as Inhibitors of HCV NS3 Protease
✍ Scribed by Velázquez, Francisco; Venkatraman, Srikanth; Wu, Wanli; Blackman, Melissa; Prongay, Andrew; Girijavallabhan, Viyyoor; Shih, Neng-Yang; Njoroge, F. George
- Book ID
- 126849150
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 180 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
HCV NS3/4A serine protease is essential for the replication of the HCV virus and has been a clinically validated target. A series of HCV NS3/4A protease inhibitors containing a novel acylsulfamoyl benzoxaborole moiety at the P1' region was synthesized and evaluated. The resulting P1-P3 and P2-P4 mac
The Hepatitis C Virus (HCV) is a major health hazard and its infection is a leading cause of chronic liver disease world wide. In our efforts toward the discovery of a back up to our first clinical candidate, Boceprevir (SCH 503034), we approached the depeptidization of the molecule through macrocyc