HCV NS3/4A serine protease is essential for the replication of the HCV virus and has been a clinically validated target. A series of HCV NS3/4A protease inhibitors containing a novel acylsulfamoyl benzoxaborole moiety at the P1' region was synthesized and evaluated. The resulting P1-P3 and P2-P4 mac
Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease
โ Scribed by Charles Z. Ding; Yong-Kang Zhang; Xianfeng Li; Yang Liu; Suoming Zhang; Yasheen Zhou; Jacob J. Plattner; Stephen J. Baker; Liang Liu; Maosheng Duan; Richard L. Jarvest; Jingjing Ji; Wieslaw M. Kazmierski; Matthew D. Tallant; Lois L. Wright; Gary K. Smith; Renae M. Crosby; Amy A. Wang; Zhi-Jie Ni; Wuxin Zou; Jon Wright
- Book ID
- 104005030
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 663 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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## Abstract For Abstract see ChemInform Abstract in Full Text.