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Application of the comet assay method in clinical studies

✍ Scribed by Petra Fikrová; Rudolf Štětina; Miloslav Hronek; Radek Hyšpler; Alena Tichá; Zdeněk Zadák

Book ID
106172994
Publisher
Springer Vienna
Year
2011
Tongue
English
Weight
275 KB
Volume
123
Category
Article
ISSN
0043-5325

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The comet assay (single-cell gel electrophoresis), which measures DNA strand breaks at the level of single cells, is very easily applied to human lymphocytes, and therefore lends itself to human biomonitoring studies. For the examination of DNA base oxidation (a specific marker of oxidative damage),