13 C labeling was used to enhance the sensitivity of 13 C solid-state NMR to study the effect of tabletting on the polymorphism of a steroidal drug. The steroidal drug Org OD 14 was 13 C labeled and formulated into tablets containing only 0.5-2.5% active ingredient. The tablets were subsequently
Application of solid state 13C nmr to the study of polymorphs, clathrates and complexes
β Scribed by John A. Rdpmeester
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 235 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0009-2614
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β¦ Synopsis
Recewcd 14 May 1980 t3C IVhfR spectra, obtamed for a number of clathrates, hydrogen-bonded complexes and polymorphic forms of hydroquinone, proved to be umquely related to the crystal structures. pquinols can easily be dlstingulshed from o-and yqumols, and hydroqumone in stolciuometric complcucs. Structurally induced chenucal shrfts indlcnte fmgerpnntmg capabtities for 13C NMR.
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## Abstract The principal elements of the chemical shift tensors for the phosphorus atoms in three bis(dialkoxythiophosphoryl) disulfides were determined from both static and magic angle spinning NMR spectra, using the intensities of the peaks in the spinning sidebands relative to those of the cent