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Application of Rat In Situ Single-pass Intestinal Perfusion in the Evaluation of Presystemic Extraction of Indinavir Under Different Perfusion Rates

โœ Scribed by Yunn-Fang Ho; Ming-Yen Lai; Hsiu-Ying Yu; Da-Kong Huang; Wei-Cherng Hsueh; Tung-Hu Tsai; Chia-Chun Lin


Book ID
117630260
Publisher
Chinese Electronic Periodical Services
Year
2008
Tongue
English
Weight
243 KB
Volume
107
Category
Article
ISSN
0929-6646

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Methods of analyzing drug absorption data from rat intestinal-perfusion experiments are discussed in terms of mass-transfer resistances, or reciprocal permeabilities, and mass balances. Typically, a two-resistance model is used to determine the dimensionless effective permeability (P\*eff) by measur