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Application of combinatorial techniques in the synthesis of unsymmetrically substituted 5,15-diphenylporphyrins

✍ Scribed by Kerry J Elgie; Martin Scobie; Ross W Boyle

Book ID
104210115
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
206 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

Combinatorial techniques, both solid and solution phase, have been applied to the synthesis of unsymmetrically substituted 5,15-diphenylporphyrins. 5-(4-Hydroxyphenyl)-15-pentafluorophenylporphyrin can be loaded onto solid supports and substituted on the pentafluorophenyl ring with thiols. Diversity is then expanded by cleavage and solution phase substitution of the second phenyl ring using a solid supported base.

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