Concerning the Synthesis of 3,7,13,17-Tetramethyl-5,15-diphenylporphyrin, a Sterically Hindered Porphyrin
β Scribed by Valasinas, Aldonia; Hurst, Jorge; Frydman, Benjamin
- Book ID
- 120190563
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 61 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3263
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## Abstract The synthesis of the title compounds (**1** and **3**) is described. Some of the compounds prepared were found to be active against a number of pathogenic microorganisms __in vitro.__ Structureβactivity relationship is briefly discussed.
Porphyrins with steric hindrance at the periphery are known to exhibit severely non-planar macrocycle conformations. Among other dodecasubstituted porphyrins, the title compound has been studied widely and shows a typical saddle-distorted macrocycle. The specific conformation of the porphyrin leads