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Application of Biochemical Methods in Enantioselective Synthesis of Bioactive Natural Products

✍ Scribed by Kenji Mori

Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
439 KB
Volume
101
Category
Article
ISSN
0037-9646

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✦ Synopsis

Enzymes as well as yeasts were used in enantioselective syntheses of bioregulators such as hormones and semiochemicals. Lipases and esterases were employed in achieving optical resolution, conversion of meso-compounds to optically active compounds, and macrolactonization. Lactase effected glucosidation of a phenolic hydroxy ketone without any protection of the functional groups. Yeasts provided a variety of optically active hydroxy esters and ketones, which served as versatile non-racemic chiral building blocks.

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