Organocatalytic Synthesis of Drugs and Bioactive Natural Products

✍ Scribed by Renata Marcia de Figueiredo; Mathias Christmann

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 515 KB
• Volume: 2007
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200700032

✦ Synopsis

Abstract

Catalytic reactions are a key element in the design of sustainable chemical processes. As witnessed in the field of transition metal‐catalysed processes, only those reactions that are reliable over a broad substrate range and tolerant toward a multitude of functional groups have found their way into the repertoire of preparative chemists. Natural product synthesis provides a good benchmark for the maturity of a new synthetic method and in this microreview we discuss the scope and limitations of organocatalytic reactions in the synthesis of biologically important molecules. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)