Novel Drugs Are Being Developed Which Interact With The Programmed Cell Death (apoptotic) Machinery In Cancer Cells, Thereby Causing These Cells To Commit Suicide And To Be Removed From The Body. Research Is Also Directed To Investigate Why The Cancer Cells Sometimes Lose The Ability To Undergo Apoptosis After A Certain Period Of Time And Methods Are Being Developed To Reactivate This Cell Death Process. This Book Is Intended For Workers In The Field And Clinicians As A Useful Guide Of The State Of Affairs In This Exciting Field Which May Offer More Effective Possibilities For Treatment Of Cancer Patients. Mels Sluyser Is The Editor Of The Journals Apoptosis And Anti-cancer Drugs. He Brings Together A Collection Of Papers Written By The World's Leading Experts In These Fields. 1. Disfunction Of The Apoptotic Pathway In Cancer Cells / Lily Yang -- 2. Calcium Signaling And Apoptosis Resistance Of Cancer Cells / Natalia Prevarskaya, Roman Skryma And Yaroslav Shuba -- 3. Cell Clearance And Cancer By Bengt Fadeel -- 4. Specific, Pro-poptotic Cell-signaling: Design Of Novel, Recombinant Targeted Antitumor Agents Operating Exclusively Through Modulation Of Cellular Apoptotic Events: Novel, Targeted Pro-apoptotic Therapeutic Agents / Yuying Liu, Lawrence H. Cheung And Michael G. Rosenblum -- 5. Targeting Oncogenes Which Regulate Apoptosis / Andrew C. Phillips -- 6. Targeting Cyclins To Cause Cancer Cell Apoptosis / Suparna Mazumder, Dragos Plesca And Alexandru Almasan -- 7. Apoptosis Induction By Tumor-targeted Toxins / Andrew Thorburn -- 8. Targeting Cell-death Pathways In Multiple Myeloma: Therapeutic Implications / Dharminder Chauhan And Kenneth Anderson -- 9. Cephalostatin 1-induced Apoptosis In Tumor Cells Selective Induction Of Smac/diablo Release / Verena M. Dirsch And Angelika M. Vollmar -- 10. Hamlet; A Novel Tool To Identify Apoptotic Pathways In Tumor Cells 223 / Caroline Duringer, Oskar Hallgren, Lotta Gustafsson, Jenny Petterson, Ann-kristin Mossberg, Taras Manilov And Catharina Svanborg -- 11. Cancer Immunotherapy: On The Trail Of A Cure? / Thomas S. Griffith, Troy J. Kemp1, Aaron T. Ludwig, Jill M. Moore, And Rebecca L. Vanoosten -- 12. Histone Deacetylase Inhibitors As A Treatment Of Trail-resistant Cancers / Jiri Neuzil, Ladislav Andera And Brian Gabrielli -- 13: Basis Of Cell Kill Following Clinical Radiotherapy / Oliver Faulhaber And Robert G Bristow -- 14. Imaging Of Apoptotic Cells In Vivo By Juhana Hakumaki -- 15. Apoptosis-inducing Anticancer Drugs In Clinical Trials / Wei Hu And John J. Kavanagh. [edited] By Mels Sluyser. Errata Slip Inserted. Includes Bibliographical References And Index. Mode Of Access: World Wide Web.