Application of Alpha7 Nicotinic Acetylcholine Receptor Agonists in Inflammatory Diseases: An Overview
β Scribed by Mario B. Marrero; Merouane Bencherif; Patrick M. Lippiello; Rudolf Lucas
- Book ID
- 106494093
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 172 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0724-8741
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It is considered that activation of nicotinic a 7 receptors (a 7 nAChR) is useful for the treatment of cognitive disturbances in schizophrenia and Alzheimer's disease. Recently, selective a 7 nAChR agonists have been discovered and are used to validate the a 7 nAChR as a drug target for the treatmen
## Abstract A group of agonists for the Ξ±7 neuronal nicotinic acetylcholine receptors (nAChRs) was investigated, and their free energies of binding Ξ__G__~bind~ were calculated by applying the molecular mechanics PoissonβBoltzmann surface area (MMβPBSA) approach. This method, based on molecular dyn