๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Application of a Thermodynamic Model to the Prediction of Phase Separations in Freeze-Concentrated Formulations for Protein Lyophilization

โœ Scribed by Martin C. Heller; John F. Carpenter; Theodore W. Randolph


Book ID
115567498
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
234 KB
Volume
363
Category
Article
ISSN
0003-9861

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Protein formulation and lyophilization c
โœ Martin C. Heller; John F. Carpenter; Theodore W. Randolph ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 569 KB

Hemoglobin has been previously shown to unfold during freeze drying when lyophilized from formulations that undergo freeze-concentration induced phase separation (Heller et al. 1997. Biotechnol Prog 13:590-596). In this report, we show that such damage may be avoided using kinetic strategies to arre

The study of phase separation in amorpho
โœ Adora M. Padilla; Michael J. Pikal ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 325 KB ๐Ÿ‘ 1 views

Phase separation in amorphous freeze-dried proteins systems is speculated to occur, but limitations in methods of detection have hindered progress in identifying and studying this phenomenon. We present here preliminary results obtained on model two-component protein-stabilizer systems that illustra

Application of a finite initial separati
โœ B. Stevens ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 469 KB

The Stem-Volmer equation in the Smoluchowski-Collins-Kimball approximation is modified by the use of a most probable nearest neighbour separation as an upper integration limit of the time-independent flux equation. The resulting relationship provides a description of the experimental relative fluore