Hemoglobin has been previously shown to unfold during freeze drying when lyophilized from formulations that undergo freeze-concentration induced phase separation (Heller et al. 1997. Biotechnol Prog 13:590-596). In this report, we show that such damage may be avoided using kinetic strategies to arre
Application of a Thermodynamic Model to the Prediction of Phase Separations in Freeze-Concentrated Formulations for Protein Lyophilization
โ Scribed by Martin C. Heller; John F. Carpenter; Theodore W. Randolph
- Book ID
- 115567498
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 234 KB
- Volume
- 363
- Category
- Article
- ISSN
- 0003-9861
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