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Appearance of guillain-barré syndrome in patients during corticosteroid treatment

✍ Scribed by Israel Steiner; Itzhak Wirguin; Oded Abramsky

Publisher
Springer
Year
1986
Tongue
English
Weight
321 KB
Volume
233
Category
Article
ISSN
0340-5354

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✦ Synopsis

Three patients developed acute Guillain-Barré syndrome while on steroid treatment. The first patient suffered from ulcerative colitis and developed Guillain-Barré syndrome when the steroid dosage was being tapered. Another patient with long-standing multiple sclerosis received steroids during relapse and the Guillain-Barré syndrome appeared while treatment was reduced. The third patient, with aqueductal stenosis and ventriculoatrial shunt, who received steroids when malfunction of the shunt was suspected, developed Guillain-Barré syndrome while steroids were being tapered. Based on the putative immune pathogenesis of inflammatory demyelinating polyneuropathy, the occurrence of the syndrome in these patients could have been due to a selective effect of low-dose steroids on a specific, maybe suppressor lymphocyte subpopulation.

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