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APP and PS-1 transgenic mice

✍ Scribed by David R. Borchelt; Christian Lesuisse; Vicki Gonzales; Jeffrey Anderson; Michael K. Lee; Donald L. Price; Philip C.Y. Wong; Steve Wagner


Book ID
117411717
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
195 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract Memantine is a moderate‐affinity, uncompetitive N‐methyl‐D‐aspartate (NMDA) receptor antagonist that stabilizes cognitive, functional, and behavioral decline in patients with moderate to severe Alzheimer's disease (AD). In AD, the extracellular deposition of fibrillogenic amyloid‐β pept