In childhood acute lymphoblastic leukaemia there are large interpatient variations in levels of the apoptosis-regulating proteins Bax and Bcl-2, but the molecular basis for this variation is unknown. Point-mutations in bax have been reported in cell lines derived from haematological malignancies. Fr
Apoptotic index, Fas and bcl-2 in initial and relapsed childhood acute lymphoblastic leukaemia
β Scribed by G. Stammler; A. Sauerbrey; F. Zintl; M. Volm
- Book ID
- 111561522
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 237 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1360-8185
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## Abstract We have previously demonstrated induction of __O__βacetylated sialoglycoproteins on lymphoblasts of childhood acute lymphoblastic leukaemia (ALL). These molecules promote survival of lymphoblasts by preventing apoptosis. Although __O__βacetylated sialoglycoproteins are over expressed, t
## Abstract Twenty children received methylprednisolone (1 g/m^2^), daily for 5 to 8 days, as initial single agent therapy for relapsed acute lymphoblastic leukaemia. Bone marrow blasts were reduced to <5% in 2 and 5β10% in 3 of 12 patients with bone marrow relapses. In 3/9 with central nervous sys