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Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

✍ Scribed by Häcki, Jürg; Egger, Lotti; Monney, Laurent; Conus, Sébastien; Rossé, Thierry; Fellay, Isabelle; Borner, Christoph


Book ID
110063917
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
653 KB
Volume
19
Category
Article
ISSN
0950-9232

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## Abstract Enhanced spiral ganglion neuron (SGN) survival and regeneration of peripheral axons following deafness will likely enhance the efficacy of cochlear implants. Overexpression of Bcl‐2 prevents SGN death but inhibits neurite growth. Here we assessed the consequences of Bcl‐2 targeted to ei