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Apoptotic and effector pathways in autoimmunity

โœ Scribed by Alexander V Chervonsky

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
76 KB
Volume
11
Category
Article
ISSN
0952-7915

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โœฆ Synopsis

Programmed cell death is an important anti-autoimmune mechanism used to delete autoreactive lymphocytes and to limit the spread both of viral infections and of tissue damage caused by immune responses. However, in autoimmune diseases, activation of programmed cell death by effector mechanisms that are similar to the normal immune response leads to augmented destruction of the targeted tissues.

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