Systemic lupus erythematosus (SLE) is characterized by the production of high-titer IgG-class antinuclear antibodies (ANA). The principal targets of ANA in SLE include chromatin (DNA, histones, and other associated proteins) and ribonucleoproteins, such as small nuclear RNPs (snRNPs) that process pr
โฆ LIBER โฆ
Epitope mimics and determinant spreading: pathways to autoimmunity
โ Scribed by A. D. Farris; C. L. Keech; T. P. Gordon; J. McCluskey *
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 159 KB
- Volume
- 57
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
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n the early 1900s, controversies between the Ehrlich school and the Metchnikoff school of immunology laid the foundation for our current notions of self-tolerance and autoimmunity. The experiments of Ehrlich and Morgenroth showed that animals did not produce autoantibodies to their own erythrocytes