Apoptosis induction of persicae semen extract in human promyelocytic leukemia (hl-60) cells
β Scribed by Kwon Hee-Young; Hong Seon-Pyo; Hahn Dong-Hoon; Kim Jeong Hee
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 643 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0253-6269
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In a previous study, we showed that geranylgeraniol (GGO) is a potent inducer of apoptosis in human leukemia cells, including HL60 promyelocytic leukemia cells. The present study describes the effects of activators of protein kinase C (PKC) on GGO-induced apoptosis in various lines of leukemia cells
## Abstract Various compounds active in promoting in vitro differentiation of certain murine leukemia cell lines (Friend erythroleukemia cells and mouse myeloid leukemia cells) were tested for their capacity to induce differentiation of HLβ60 cells, a human promyelocytic leukemia cell line capable
Treatment of HL-60 cells with micromolar concentrations of N 6 -benzyladenosine (N 6 -benzylaminopurine riboside [BAPR]) led to the occurrence of apoptosis in a concentration-dependent manner. Incubation period as short as 2 h in the presence of BAPR was sufficient for triggering irreversible change