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Apoptosis induced by extracellular glutathione is mediated by H2O2 production and DNA damage

✍ Scribed by Paola Perego; Laura Gatti; Nives Carenini; Laura Dal Bo; Franco Zunino

Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
132 KB
Volume
87
Category
Article
ISSN
0020-7136

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Oxidative damage to sarcoplasmic reticulum Ca2+-pump induced by Fe2+/H2O2/ascorbate is not mediated by lipid peroxidation or thiol oxidation and leads to protein fragmentation
✍ Roger F. Castilho; Paulo C. Carvalho-Alves; Anibal E. Vercesi; SΓ©rgio T. Ferreir πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 904 KB

The major protein in the sarcoplasmic reticulum (SR) membrane is the Ca2+ transporting ATPase which carries out active Ca2+ pumping at the expense of ATP hydrolysis. The aim of this work was to elucidate the mechanisms by which oxidative stress induced by Fenton's reaction (Fe(2+)+H2O2-->HO.+OH-+Fe3