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Apoptosis induced by crocidolite asbestos in human lung epithelial cells involves inactivation of Akt and MAPK pathways

✍ Scribed by Aleksander Baldys; Priyadarshini Pande; Tariq Mosleh; Sun-Hee Park; Ann E. Aust


Publisher
Springer
Year
2006
Tongue
English
Weight
888 KB
Volume
12
Category
Article
ISSN
1360-8185

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## Abstract Regulation and function of PI 3K/Akt and mitogen‐activated protein kinases (MAPKs) in doxorubicin‐induced cell death were investigated in human lung adenocarcinoma cells. Doxorubicin induced dose‐dependent apoptosis of human lung adenocarcinoma NCI‐H522 cells. Prior to cell death, both