We have previously demonstrated that 2-chloro-adenosine (2-CA) can induce apoptosis of rat astroglial cells (Abbracchio et al. [1995] Biochem. Biophys. Res. Commun. 213:908-915). In the present study, we have characterized, for the first time, the effects induced on a human astrocytoma cell line (AD
Apoptosis by 2-chloro-2′-deoxy-adenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells
✍ Scribed by D. Barbieri; M.P. Abbracchio; S. Salvioli; D. Monti; A. Cossarizza; S. Ceruti; R. Brambilla; F. Cattabeni; K.A. Jacobson; C. Franceschi
- Book ID
- 117410318
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 658 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0197-0186
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Both the adenosine analogue 2-chloro-adenosine (2-CA) and the reducing sugar deoxy-D-ribose (dRib) induce apoptosis of astroglial cells in rat brain primary cultures (Abbracchio et al.: Biochem Biophys Res Commun 213:908-915, 1995). The present study was undertaken to elucidate by both morphological
## Abstract We studied effects of 2‐chloro‐N^6^‐(3‐iodobenzyl)‐adenosine‐5′‐N‐methyluronamide (Cl‐IB‐MECA) on apoptosis induction in the K562/Dox cell line, which overexpressed P‐glycoprotein (P‐gp, __ABCB1__, __MDR1__). We found that the K562/Dox cell line was significantly more resistant to Cl‐IB