Apoptosis and the treatment of chronic lymphoid malignancies: the B-chronic lymphocytic leukemia (B-CLL) model
โ Scribed by F. Caligaris-Cappio; D. Gottardi; A. Alfarano; A.M. De Leo; A. Stacchini; L. Bergui
- Book ID
- 116167759
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 96 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0959-8049
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๐ SIMILAR VOLUMES
Analysis of peripheral blood (>85% CD19+/CD5+ B) lymphocytes, obtained from 44 patients affected by B chronic lymphoid leukemia (B-CLL), showed that surface TNF-related apoptosis inducing ligand (TRAIL) was expressed in all samples and at higher levels with respect to unfractionated lymphocytes and
Over the last decade, the active role of the microenvironment in the pathogenesis of B cell lymphomas has been recognized, delivering signals that favor clonal expansion and drug resistance. We are only beginning to understand the complex cross talk between neoplastic B cells and the tissue microenv