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Apolipoprotein Eε4 modifies Alzheimer's disease onset in an E280A PS1 kindred

✍ Scribed by Pau Pastor; Catherine M. Roe; Andrés Villegas; Gabriel Bedoya; Sumi Chakraverty; Gloria García; Victoria Tirado; Joanne Norton; Silvia Ríos; Maribel Martínez; Kenneth S. Kosik; Francisco Lopera; Alison M. Goate


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
110 KB
Volume
54
Category
Article
ISSN
0364-5134

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E280A PS-1 mutation causes Alzheimer's d
✍ Corinne L. Lendon; Alonso Martinez; Isabel Maria Behrens; Kenneth S. Kosik; Luci 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 216 KB 👁 2 views

A single base substitution of a glutamic acid to an alanine codon 280 was found in the presenilin-1 (PS-1) gene on chromosome 14 in affected individuals in each of seven Colombian early-onset Alzheimer's disease (AD) kindreds. The mutation segregated with disease in kindreds tested. In the largest k