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Apolipoprotein E4 isoform-specific actions on neuronal cells in culture

✍ Scribed by Makoto Michikawa; Katsuhiko Yanagisawa

Book ID
114096641
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
230 KB
Volume
107
Category
Article
ISSN
0047-6374

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## Abstract We determined the molecular mechanisms underlying apolipoprotein E (ApoE)‐isoform‐dependent lipid efflux from neurons and ApoE‐deficient astrocytes in culture. The ability of ApoE3 to induce lipid efflux was 2.5‐ to 3.9‐fold greater than ApoE4. To explore the contributions of the amino‐