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Apolipoprotein E genotype is related to nitric oxide production in platelets

✍ Scribed by Tania Marcourakis; Valéria S. Bahia; Elisa M. Kawamoto; Carolina D. Munhoz; Renata Gorjão; Rinaldo Artes; Fernando Kok; Paulo Caramelli; Ricardo Nitrini; Rui Curi; Cristoforo Scavone

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
139 KB
Volume
26
Category
Article
ISSN
0263-6484

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✦ Synopsis

Abstract

The presence of the __ε__4 allele of apolipoprotein E (APOE) is considered a risk factor for sporadic Alzheimer's disease (AD). Our recent data demonstrated that the systemic modulation of oxidative stress in platelets and erythrocytes is disrupted in aging and AD. In this study, the relationship between APOE genotype and oxidative stress markers, both in AD patients and controls, was evaluated. The AD group showed an increase in the content of thiobarbituric acid‐reactive substances (TBARS) and in the activities of nitric oxide synthase (NOS) and Na, K‐ATPase, when compared to controls. Both groups had a similar cGMP content and superoxide dismutase activity. APOE __ε__4 allele carriers showed higher NOS activity than non‐carriers. These results suggest a possible influence of APOE genotype on nitric oxide (NO) production that might enhance the effects of age‐related specific factor(s) associated with neurodegenerative disorders. Copyright © 2008 John Wiley & Sons, Ltd.

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