A common polymorphism in the α1-antichymotrypsin (ACT) gene has been found to modify the APOE\*4-associated risk of Alzheimer's disease due to an apparent interaction between the two loci. This study was undertaken to determine the gender-and age-related distributions of these two polymorphisms in t
Apolipoprotein E and α1-antichymotrypsin polymorphism in Alzheimer's disease
✍ Scribed by Benedetta Nacmias; Andrea Tedde; Stefania Latorraca; Silvia Piacentini; Laura Bracco; Luigi Amaducci; Dr Sandro Sorbi; Bianca Maria Guarnieri; Concetta Petruzzi; Luigi Ortenzi
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 313 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0364-5134
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Alzheimer's disease, the most frequent form of senile dementia, presents in the vast majority of cases as a multifactorial trait, where a series of genetic and environmental risk factors converge. The increasing body of data, both epidemiological and functional, is strengthening the evidence that ap
To examine the possible involvement of the alpha-1-antichymotrypsin gene (ACT) polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed genotypes of the ACT and apolipoprotein E gene (APOE) among 110 Korean patients with probable AD and 209 nondemented controls. No significant diff