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Apolipoprotein E and Alzheimer's disease: molecular mechanisms and therapeutic opportunities

✍ Scribed by Angel Cedazo-Mínguez


Book ID
114778314
Publisher
Carol Davila University of Medicine Bucharest, Romania
Year
2007
Tongue
English
Weight
143 KB
Volume
11
Category
Article
ISSN
1582-1838

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Apolipoprotein E and Alzheimer disease:
✍ Liu, Chia Chan (author);Kanekiyo, Takahisa (author);Xu, Huaxi (author);Bu, Guoju 📂 Article 📅 2013 🏛 Nature Publishing Group 🌐 English ⚖ 740 KB

| Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants of Alzheimer disease (AD) risk: individuals carrying the ε4 allele are at increased risk of AD compared with those carryi