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Apolipoprotein E, a Gene with Complex Biological Interactions in the Aging Brain

✍ Scribed by Allen D. Roses


Book ID
115641413
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
645 KB
Volume
4
Category
Article
ISSN
0969-9961

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Apolipoprotein (apo) E and its polymorphism are linked to the pathogenesis of late-onset and sporadic Alzheimer's disease (AD). ApoE facilitates the deposition and fibrillogenesis of beta-amyloid (Abeta), and may participate in Abeta clearance. We recently found that apo(E-AII) complex binds to Abet