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Aphidicolin inhibits DNA synthesis by DNA polymerase α and isolated nuclei by a similar mechanism

✍ Scribed by Krokan, Hans; Wist, Erik; Krokan, Ruth Haaland

Book ID
126155229
Publisher
Oxford University Press
Year
1981
Tongue
English
Weight
479 KB
Volume
9
Category
Article
ISSN
0305-1048

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DNA polymerase α inhibition by aphidicol
DNA polymerase α inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes
✍ Thomas W. Glover; Carol Berger; Jane Coyle; Barbara Echo 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 987 KB

Aphidicolin, a specific inhibitor of DNA polymerase alpha, is known to induce chromosomal aberrations. At concentrations that did not greatly affect mitotic index, aphidicolin induced a striking number of chromosome gaps and breaks distributed in a highly nonrandom manner in cultured human lymphocyt