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Antiviral CD4 and CD8 T-cell memory: differences in the size of the response and activation requirements

โœ Scribed by Whitmire, J. K.; Murali-Krishna, K.; Altman, J.; Ahmed, R.

Book ID
120152875
Publisher
The Royal Society
Year
2000
Tongue
English
Weight
636 KB
Volume
355
Category
Article
ISSN
0080-4622

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta