Dichloromethane and ethanol extracts of 12 plants with a history of use in traditional medicine, were tested for antiviral activity against herpes simplex type I. The most potent inhibition was shown by ethanol extracts of Eugenia jambos, Cistus populifolius, Lippia alba, Chiranthodendron pentadacty
Antiviral activity of some South American medicinal plants
β Scribed by M. J. Abad; P. Bermejo; S. Sanchez Palomino; L. Carrasco; X. Chiriboga
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 69 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0951-418X
No coin nor oath required. For personal study only.
β¦ Synopsis
Folk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Extracts prepared from 10 South American medicinal plants (Baccharis trinervis, Baccharis teindalensis, Eupatorium articulatum, Eupatorium glutinosum, Tagetes pusilla, Neurolaena lobata, Conyza floribunda, Phytolacca bogotensis, Phytolacca rivinoides and Heisteria acuminata) were screened for in vitro antiviral activity against herpes simplex type I (HSV-1), vesicular stomatitis virus (VSV) and poliovirus type 1. The most potent inhibition was observed with an aqueous extract of B. trinervis, which inhibited HSV-1 replication by 100% at 50-200 mg/mL, without showing cytotoxic effects. Good activities were also found with the ethanol extract of H. acuminata and the aqueous extract of E. articulatum, which exhibited antiviral effects against both DNA and RNA viruses (HSV-1 and VSV, respectively) at 125-250 mg/mL. The aqueous extracts of T. pusilla (100-250 mg/mL), B. teindalensis (50-125 mg/mL) and E. glutinosum (50-125 mg/mL) also inhibited the replication of VSV, but none of the extracts tested had any effect on poliovirus replication.
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