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Antiviral activity of polynucleotides Poly(2′-fluoro-2′-deoxyuridylic acid)

✍ Scribed by Erik De Clercq; Borek Janik

Book ID
115745331
Publisher
Elsevier Science
Year
1973
Weight
396 KB
Volume
324
Category
Article
ISSN
0005-2787

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Effect of polyamines on the uptake of po
Effect of polyamines on the uptake of poly (2′-fluoro-2′-deoxyuridylic acid) by a mammalian cell line
✍ Janik, Borek ;Sommer, Ronald G. 📂 Article 📅 1976 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 322 KB

## Abstract VERO cells can take up poly(dUfl)^1^ from the medium. The uptake involves surface adsorption and, most probably, intracellular penetration. Part of the poly(dUfl) is hydrolyzed during incubation with the cells but the hydrolysis products are not incorporated into de novo synthesized nuc