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Antitumor Potential of Acyclic Nucleoside Phosphonates

โœ Scribed by Clercq, E. De; Andrei, G.; Balzarini, J.; Hatse, S.; Liekens, S.; Naesens, L.; Neyts, J.; Snoeck, R.


Book ID
126688918
Publisher
Taylor and Francis Group
Year
1999
Tongue
English
Weight
759 KB
Volume
18
Category
Article
ISSN
0732-8311

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Synthesis of acyclic nucleoside phosphon
โœ Frank Wormstรคdt; Michael Gรผtschow; Kurt Eger; Ute Brinckmann ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 426 KB

## Abstract Reaction of 6โ€chloropyrimidines with diethyl [(2โ€aminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5โ€substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and tested against herpes simplex viruses (