Antitumor effect of methylglyoxal bis(butylamidinohydrazone), a new inhibitor of S-adenosylmethionine decarboxylase, against human erythroid leukemia K 562 cells

Antitumor effect of methylglyoxalbis(3-a

Antitumor effect of methylglyoxalbis(3-aminopropyl-amidinohydrazone), a new inhibitor ofS-adenosylmethionine and ornithine decarboxylases, on human erythroid leukemia K562 cells

✍ H. Hibasami; T. Tsukada; S. Maekawa; M. Sakurai; S. Shirakawa; K. Nakashima 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 346 KB

Methylglyoxal bis(3-aminopropylamidinohydrazone (MGBA) inhibited S-adenosylmethionine decarboxylase (AdoMetDC) activity competitively with S-adenosylmethionine (AdoMet), showing a Ki value of 2.60 x 10(-5) M. It also inhibited ornithine decarboxylase competitively with ornithine, showing a Ki value