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Antitumor effect of KT6124, a novel derivative of protein kinase inhibitor K-252a and its mechanism of action

โœ Scribed by Shiro Akinaga; Tadashi Ashizawa; Katsushige Gomi; Hiroe Ohno; Makoto Morimoto; Chikara Murakata; Masami Okabe

Book ID
104887016
Publisher
Springer
Year
1992
Tongue
English
Weight
724 KB
Volume
29
Category
Article
ISSN
0344-5704

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Concentration-dependent stimulation and
Concentration-dependent stimulation and inhibition of growth cone behavior and neurite elongation by protein kinase inhibitors KT5926 and K-252a
โœ Oberstar, Joel V. ;Challacombe, Jean F. ;Roche, Florence K. ;Letourneau, Paul C. ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 281 KB ๐Ÿ‘ 2 views

We examined the concentration- and time-dependent effects of two related protein kinase inhibitors, KT5926 and K-252a, on neurite formation and nerve growth cone migration of chick embryo sensory neurons. The effects of these drugs on neurite formation over an 18-h period were dissimilar. KT5926 sti