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Potent and preferential inhibition of Ca2+ / calmodulin-dependent protein kinase II by K252a and its derivative, KT5926

✍ Scribed by Yoshiaki Hashimoto; Toshihumi Nakayama; Tamio Teramoto; Hirokazu Kato; Tsuyoshi Watanabe; Makoto Kinoshita; Kazuhisa Tsukamoto; Kazuyuki Tokunaga; Kiyoshi Kurokawa; Satoshi Nakanishi; Yuzuru Matsuda; Yoshiaki Nonomura


Book ID
117055627
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
326 KB
Volume
181
Category
Article
ISSN
0006-291X

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We examined the concentration- and time-dependent effects of two related protein kinase inhibitors, KT5926 and K-252a, on neurite formation and nerve growth cone migration of chick embryo sensory neurons. The effects of these drugs on neurite formation over an 18-h period were dissimilar. KT5926 sti

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## Abstract We recently reported that Ca^2+^/calmodulin‐dependent protein (CaM) kinase II is involved in light‐induced phase delays and __Per__ gene induction in the suprachiasmatic nucleus (SCN). To clarify the activation mechanisms of CaM kinase II by glutamate receptor stimulation in the SCN, we