Antitumor effect of interleukin 7 in combination with local hyperthermia in mice bearing B16a melanoma cells
โ Scribed by Bo Wu; Rong-Nian Shen; Wen-Xue Wang; Hal E. Broxmeyer; Dr. Li Lu
- Book ID
- 112212496
- Publisher
- AlphaMed Press
- Year
- 1993
- Tongue
- English
- Weight
- 913 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1066-5099
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## Abstract Dendritic cells (DC) are potent antigenโpresenting cells that can present tumor antigens chaperoned by heat shock proteins (HSPs), while local hyperthermia (LHT) can increase the expression of HSPs. In this study, we determine if intratumoral injection of immature DC after LHT (LHT+ITโD
## Abstract The synergistic effect of local hyperthermia (LHT) with intratumor injection (i.t.) of cisโdiamminedichloroplatinum (II) (DDP) was studied using a rodent model with implanted B16 melanoma tumors. The hindfoot of the C57BL/6 mouse bearing the tumor was placed in a water bath at 42.5 ยฑ 0.